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APOE and frontotemporal dementia  </B>
   Lead Investigator:    Rahul Desikan
   Institution      :    UCSD
   E-Mail           :    rahuldesikan@gmail.com
   Proposal ID      :    599
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>A substantial amount of prior work indicates that the E2 and E4 alleles of        apolipoprotein E (APOE) impact Alzheimer's disease (AD) age of onset. However,    the relationship between APOE and frontotemporal dementia (FTD) has not been      evaluated in a large, neuropathologically-confirmed, population based cohort.     Additionally, the relationship between APOE and cognitive changes and the         impact of cardiovascular risk factors on APOE-associated FTD risk factors is      not known. In this proposal, using the large population based NACC cohort, we     will evaluate the relationship between the E2, E3 and E4 APOE alleles and the     various FTD subtypes. We will additionally evaluate the relationship between      cognitive changes and APOE on FTD associated neuropathology as well as the role                                                                                  of cardiovascular risk factors, in combination with APOE alleles, on impacting    FTD age of onset. </textarea>